Hi I know this is rather late, but I’m really struggling to wrap my mind around interaction between T and B lymphocytes, cell mediated immunity and antibody mediated immunity - I don’t understand it extensively and I don’t really know how much I need to know of it anyway! I would forever appreciate any help at all!!!
This is basically what I've remembered:
Think of the immune response as centered around helper T-cells (the starting point)
Helper T-cells have surface receptor proteins that are specific to an antigen, meaning they are able to detect a specific antigen
The way this detection can occur is by the helper T-cell recognising the antigen as it is displayed on MHCII molecules
MHCII molecules are glycoprotein molecules and are found on macrophages and B-cells, so either of these can hold the antigen on the surface of the MHCII molecule.
A macrophage can ingest an antigen and the fragments of the antigen are displayed on the MHCII molecule (can't think of a good analogy but maybe some jelly with the antigen fragments as sprinkles on top of jelly). So once the helper T-cell has the antigen brought by a B-cell or macrophage, its specific surface receptor protein will recognise the antigen and process it.
Then, the helper T-cell releases these 'signalling' chemicals called cytokines. The specific cytokine 'interleukin-2' basically stimulates B-cells to differentiate into PLASMA B-cells and MEMORY B-cells. T-cells also differentiate into CYTOTOXIC, MEMORY and SUPPRESSOR T-cells.
Plasma B-cells are important for the immune response as they can secrete antibodies, which specifically can inactivate or destroy the matching antigen.
Another mechanism comes into play for cytotoxic T-cells, which are MHCI molecules. These essentially mark infected body cells as targets for cytotoxic T-cells, which are ALSO specific to the antigen. The cytotoxic T-cells will move to find the infected cells, attach to them and release a chemical called 'perforin' which perforates the cell and causes it to lyse, which kills the infected cell.
Apart from this method of forming differentiated T and B cells, they can also be activated directly by antigens. Probably some stuff I missed, but if you know that in general you should be fine!