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The allostatic model adopts the perspective of the biopsychosocial framework by explaining the stress response in terms of the complex combined interaction of biological, psychological and social factors. E.g. our perception or appraisal (psychological) of a potential stressor (biological, psychological or social factor) will determine whether the HPA axis and systems involved in an allostatic response are activated (biological factor). Appraisal is influenced by prior experience (psychological factor), the context in which it occurs and our current circumstances (social factor), as well as underlying influences of our genetic inheritance (biological factor). When the allostatic response is activated (biological factor), the brain will detect and regulate bodily processes and determine how quickly they will return to their normal levels (biological), taking account of the stressor and the context (biological, psychological, social). The brain will also play a role in the use of coping strategies that may exacerbate or alleviate the stress response (biological, psychological, social.)