Seems like you may have already made up your mind, GalacticProcess, so I won't bore you with which subjects you should or shouldn't take, I just wanted to say this:
It can be really good to do a subject that is a bit different - it makes you think differently, and can be a refreshing change in your timetable
If you're considering going into a health sciences sort of field, I can attest that PE will help give you a bit of background knowledge and understanding. It's not completely theory based - all my friends who did PE seemed to be doing prac pretty often
It also has a bit of an overlap with some Bio content.
In terms of any subject, particularly Spesh - why not give it a shot in year 11, then if you hate it, or really struggle with it, you can drop it and change into a different subject.
The great thing about year 11 is it gives you a bit of room to safely figure out more about what you want to do/what you enjoy.
All the best